| Description |
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide -2 (GLP-2) are two important gut hormones that are believed to have therapeutic applications. The conformational and receptor interactions of these hormones have been investigated using two-dimensional proton NMR and molecular modeling techniques. In order to exploit the therapeutic potential of these peptides and to understand the molecular recognition mechanism, receptor interaction studies were performed by using docking approach with the N-terminal extracellular domain of their receptors. The docking studies have shown the formation of a tertiary complex satisfying the majority of the experimental constraints. The results of these studies may be useful for understanding the structure related functional properties for these hormones and may help in the design of new pharmaceutical agents. |