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ABSTRACT:
Designer molecules that can be used to control gene regulatory networks, synthetic gene switches or artificial transcription factors (ATFs), are highly desirable as mechanistic probes of gene regulation, as potential therapeutic agents, and as components of cell-based devices. Recent advances in the design of ATFs that activate gene transcription, especially small-molecule-based systems, will be presented. In particular, the development of Synthetic Hox mimics and their future applications in cell fate control will be discussed.
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