| Description |
Using a mouse model of maternal caloric restriction during pregnancy affecting the metabolic physiology of two generations including paternal transmission of obesity and diabetes in the second generation, we will explore two questions:
(i) Are imprinted genes more or less susceptible to environmental compromise
and hence may be ‘developmental programming genes’ and
(ii) Is the paternal experience of in utero undernutrition, resulting in metabolic defects in his
offspring, an epigenetically inherited memory transmitted via his sperm methylome?
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