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ABSTRACT:
Major depressive disorder is one of the leading causes of disability among adult population. Despite availability of several different antidepressant drugs, the treatment options are far from perfect. All currently existent antidepressant drugs are plagued with serious handicap such as a significantly delayed onset of therapeutic effect. Sustained treatment for 4-6 weeks with antidepressants is required prior to their exerting behavioral effects. This is particularly important in patients of major depression with suicidal risk. The talk will describe how manipulation of a specific neurotransmitter subtype in the brain can be used to accelerate the slow onset adaptive changes in the brain regions involved in regulation of mood and ultimately speed up the therapeutic benefits of the traditional antidepressant drug. Our recent results also provide some novel findings on the molecular mechanisms underlying another most effective and faster but uncommonly used antidepressant therapy-electroconvulsive seizure treatment.
ABOUT THE SPEAKER:
Dr. Sudhirkumar Yanpallewar is recipient of the Shri Ramakrishna Cowsik / Smt. Saraswathi Cowsik Medal for 2012.
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