Ice-Cube is a cubic kilometer neutrino detector embedded in the deep glacial ice at the South Pole. Starting in 2014, the detector has observed a diffuse flux of astrophysical neutrinos in the TeV-PeV energy range. This talk will summarize the various searches performed for the sources of these neutrinos. All sky un-triggered searches are performed, looking for the serendipitous discovery of time integrated and flaring sources, while stacking searches target specific catalogs of promising source candidates such as Supernova Remnants and Blazars. Cross correlation searches seek to identify common sources of neutrinos and other messengers such as ultra-high energy cosmic rays. A real-time alert system enables quick follow-up observations by other multi-messenger observatories, leading to the identification of neutrinos from a flaring blazar in 2018. I will explore the implications of these observations for models of cosmic ray acceleration, and the future of neutrino astronomy at the South Pole.
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