Description |
One major question in the field of genetics, meiosis and genome evolution is to understand the distribution of meiotic recombination events, which are essential for chromosome segregation, determine the genetic map and contribute to genome diversity. We have discovered a few years ago that PRDM9, a protein that has a histone methyl-transferase activity and a zinc finger DNA binding domain plays a major role in specifying the sites of meiotic recombination in humans and mice. Our current knowledge about this unexpected and fascinating control, and its implications will be presented.
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