Description |
DNA and RNA secondary structures play key regulatory roles in biological system. Targeting these secondary structures by small molecules could provide new therapeutic strategies. In this talk, I would discuss our recent work on Target Guided Synthetic (TGS) approaches using DNA and RNA secondary structures like G-quadruplex, i-motifs and HIV-1 TAR RNA as templates to synthesize their own specific ligands. Small molecule-G-quadruplex interactions are not only useful for therapeutic applications but they can also be explored for creating biomolecular devices like ion channels.
References:
1) Chemical Science 2020, 11, 2058.
2) Nature Commun. 2017, 8, 16103.
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