Chemical Sciences Seminars

Elastic Network Model in describing equilibrium properties of proteins

by Dr. Ranja Sarkar (Dept. of Chemical Sciences, TIFR, Mumbai 400005)

Monday, April 28, 2014 from to (Asia/Kolkata)
at Colaba Campus ( AG-69 )
TIFR, Colaba, Mumbai 400005
Description
In this talk, I will describe why elastic network model (ENM) is a faster alternative to standard molecular dynamics (MD) simulations in understanding the dynamics of proteins under equilibrium conditions. I will discuss the approaches taken for optimal parametrization of the model and how the parameters are used to study intrinsic flexibility of proteins. I will also talk about some future applications of ENM in studying specific functional motions of proteins.