Event calendar file
Chemical Sciences Seminars
EPR and the Binding of Molecules to Cytochrome P450 Enzymes
by Prof. Michael K. Bowman (University of Alabama, USA)
Monday, November 2, 2015
from
to
(Asia/Kolkata)
at AG-69
at AG-69
| Description |
The cytochromes P450 are a large enzymes superfamily found in every branch of life. Some isoforms help synthesize essential compounds and are attractive targets for antibiotics. Other isoforms metabolize many pharmaceutical drugs and are one source of drug interactions. Many drugs directly bind heme in the active site but our pulsed EPR studies show a new binding mode with a water as a bridge between heme and drug, sometimes retaining enzymatic activity |
