Alzheimer’s is a multifactorial disease

Alzheimer’s disease (AD) is a chronic multifactorial neurological disorder and common form of dementia. Current treatments are only symptomatic and temporary, do not directly target the mechanisms underlying the disease pathogenesis. The production, accumulation and aggregation of proteins in the human brain are considered as the major hallmarks of the disease. Reactive oxygen species (ROS) are the major sources of biomolecular and mitochondria damage, and oxidative stress in neuronal cells. Oxidative stress, mitochondrial dysfunction, neuroinflammation and microglia contribute significantly to the disease pathogenesis. In this talk, I shall provide introduction to AD, discuss current status of diagnosis and treatment, and present our multipronged strategies in developing molecular tools for differential diagnosis and amelioration of multifaceted toxicity in AD.