Chemical Sciences Seminars
Characterization of the Non-Covalent Interactions of Propofol Using Mass Resolved Spectroscopy
by Prof. José A. Fernández (The University of the Basque Country, Spain)
Wednesday, February 19, 2014
from
to
(Asia/Kolkata)
at Colaba Campus ( AG-69 )
at Colaba Campus ( AG-69 )
TIFR, Colaba
Mumbai 400005
Description |
Propofol is probably the most widely used anaesthetic and became sadly famous several years ago as the cause of dead of the pop star Michael Jackson. The molecule exerts its action by docking on the GABAA receptors in the central nervous system. But why does it like to interact with the receptor, and how is its trip until it reaches the active site? Using a combination of laser spectroscopy and quantum mechanical calculations, under a reductionist approach, we will try to shed light on the forces that govern such odyssey. |