Importance of NMR spectral simplification methods for unambiguous structural determinations of small organic molecules in solid and solution-state will be discussed. The development of solid-state NMR experimental techniques are aimed for obtaining desired spectral information, both scalar and dipolar couplings (inter nuclear distances), by simplifying complex NMR spectra. Whereas, in solution-state all the anisotropic interactions average to zero, thereby yield NMR spectra representing only the features of chemical-shift and scalar (J) couplings. However, often the solution-state 1H NMR spectra suffer from intense overlaps due to spread of J-multiplets. In solution-state, the enhanced spectral resolution has been accomplished by employing new real-time pure-shift pulse schemes that involve broadband and band-selective homodecoupling.
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