Wednesday Colloquia
Hard to break, bcoz they learned it the hard way
by Prof. Amitesh Anand (TIFR Mumbai)
Wednesday, February 23, 2022
from
to
(Asia/Kolkata)
at AG-66 and via ZOOM webinar ( Zoom link: https://zoom.us/j/97963259354?pwd=ZFZsa2xqWGJSZW5pUjZPNkNqeGlEZz09 )
at AG-66 and via ZOOM webinar ( Zoom link: https://zoom.us/j/97963259354?pwd=ZFZsa2xqWGJSZW5pUjZPNkNqeGlEZz09 )
Meeting ID: 979 6325 9354
Pass code: 04072020
Description |
The identification and diversification of antibiotics gave us hope to eradicate infectious diseases. However, after about a century, not only is the hope dashed, we are effectively walking back to the pre-antibiotic era. This problem is threatening both human and economic health. The problem lies in the under-appreciated plasticities in bacterial physiology. Bacteria respond to any intra- or extra-cellular perturbations both proximally and distally. While a proximal response is observed immediately, a distal reaction happens on an evolutionary timescale. This knowledge gap can be bridged by simulating evolution in a laboratory setup or adaptive laboratory evolution (ALE). We will discuss some examples of the significance of ALE in understanding bacterial adaptabilities with a focus on the latest heart-throb in the field of antimicrobial target discovery, i.e., bioenergetics. |