Human behavior inspired protein engineering

Our pursuit to understand human behavior starts from the day we are born. Since it
offers an interplay of multiple dimensions, it can serve as a model and provide insight into other complex questions. We will discuss how it enabled the evolution of knowledge and core principles for precisely engineering proteins and antibodies.
[1-4] It rendered the technologies for homogeneous antibody-drug conjugates (ADCs) for directed cancer chemotherapeutics and fluorophore conjugates (AFCs) for imaging-guided tumour surgery.[4,5] Besides, it creates an opportunity to realize precision therapeutics.

References

1. DIN theory: ACS Cent. Sci. 2023, 9, 137. Chem. Soc. Rev. 2024, 53, 380.
2. Reactivity hotspots: Chem. Commun. 2021, 57, 7083. Chem. Commun. 2019, 55, 1100.
3. Gly-tag® technology: Nat. Commun. 2019, 10, 2539.
4. LDM® platform: Nat. Commun. 2022, 13, 6038. Chem. Sci. 2021, 12, 6732. Angew. Chem.
Int. Ed. 2020, 59, 10332. J. Am. Chem. Soc. 2018, 140, 15114.
5. Our other ADCs: Nat. Biomed. Eng. 2019, 3, 917. Chem. Commun. 2019, 55, 9979.